Molecule Tutorials - Herong's Tutorial Examples - v1.26, by Herong Yang
Types of Genetic Testing
Provides a quick introduction on types of genetic tests including Germline tests, Somatic tests, Single gene tests, Panel test, Exome sequencing and Genom sequencing.
There are many different types of genetic tests. Here are some examples:
Germline testing - A germline cancer test is done on cells that do not have cancer. It is done to detect germline mutations, which are a genetic change in all of the cells in your body. These changes usually happen before conception and were usually passed down from a parent.
This test uses saliva, blood, skin cells that do not have any cancer cells.
Somatic testing - A Somatic cancer test is done on cell from cancel tissues. It is done to detect somatic mutations, which happen to the genetic information in cells after a person is conceived. They are not passed down from a parent.
Single gene testing - Single gene tests look for changes in only one gene. For example, TP53 gene testing.
Panel testing - A panel genetic test looks for changes in many genes in one test. Usually, a genetic panel contains genes are related to a specific objective.
Genomic testing - There are two groups of Genomic tests.
Chromosome testing - A chromosome test looks for changes in chromosomes rather than gene changes.
Gene expression testing - A gene expression test compares proteins expressed by gens in normal cells and diseased cells.
Table of Contents
Molecule Names and Identifications
Nucleobase, Nucleoside, Nucleotide, DNA and RNA
Base-Pair Insertion and Deletion
Gene Mutation Inheritance Likelihood
What Is VCF (Variant Calling Format)
"vcftools" - VCF Utility Command
What Is VAF (Variant Allele Frequency)
Gene Mutation Naming Convention
ChEMBL Database - European Molecular Biology Laboratory
PubChem Database - National Library of Medicine
INSDC (International Nucleotide Sequence Database Collaboration)
HGNC (HUGO Gene Nomenclature Committee)