Molecule Tutorials - Herong's Tutorial Examples - v1.26, by Herong Yang
Gene Mutation Inheritance Likelihood
Provides a quick introduction of gene mutation inheritance likelihood.
Gene mutations may be inherited from parents to children. The Likelihood of mutation inheritance can be explained based the following understandings.
2 chromosomes in a single chromosome pair are not 100% identical In theory, the 2 chromosomes in a single chromosome pair are complementary to each other and carry 100% identical gene sequences. But in reality, they are not.
So if a chromosome pair contains a gene mutation, it is most likely only in 1 chromosome, not both chromosomes.
Germline chromosome is randomly chosen from a single chromosome pair A sperm or egg only carries 1 of 2 chromosomes from each chromosome pair. The Likelihood of 1 of the 2 chromosomes is chosen is 50%.
So a gene mutation in 1 of 2 chromosomes in a pair only gets 50% chance to be passed to the next generation.
The picture (source: ancestrycdn.com) below demonstrates the above 2 understandings:
Table of Contents
Molecule Names and Identifications
Nucleobase, Nucleoside, Nucleotide, DNA and RNA
Base-Pair Insertion and Deletion
►Gene Mutation Inheritance Likelihood
What Is VCF (Variant Calling Format)
"vcftools" - VCF Utility Command
What Is VAF (Variant Allele Frequency)
Gene Mutation Naming Convention
ChEMBL Database - European Molecular Biology Laboratory
PubChem Database - National Library of Medicine
INSDC (International Nucleotide Sequence Database Collaboration)
HGNC (HUGO Gene Nomenclature Committee)